Protein profile

KP13_02035

Transcriptional activator protein BglJ

Genome: KpKP13

Gene: bgIJ AHE46472.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GM70
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Amino acids 208
Annotations 2
Features 19
PDB binders 0
Druggability 0.067

Overview

Basic information about this protein and its source genome.

Accession
KP13_02035
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
bgIJ AHE46472.1
Status
annotated
Amino acids
208
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
77.17

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.067
Structure A0A0H3GM70
Pocket Pocket 1
P2Rank 0.111
Structure A0A0H3GM70
Pocket Pocket 1
ColabFold model
FPocket 0.593 · Pocket 1
P2Rank 0.684 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 9 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
165 177 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
165 177 InterPro IPR000792 Transcription regulator LuxR, C-terminal
135 149 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
135 149 InterPro IPR000792 Transcription regulator LuxR, C-terminal
149 165 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
149 165 InterPro IPR000792 Transcription regulator LuxR, C-terminal
132 189 SMART SM00421 luxrmega5
132 189 InterPro IPR000792 Transcription regulator LuxR, C-terminal
98 192 Gene3D G3DSA:1.10.10.10 -
98 192 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
123 188 SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators
123 188 InterPro IPR016032 Signal transduction response regulator, C-terminal effector
50 188 PANTHER PTHR44688 -
133 185 Pfam PF00196 Bacterial regulatory proteins, luxR family
133 185 InterPro IPR000792 Transcription regulator LuxR, C-terminal
135 189 CDD cd06170 LuxR_C_like
135 189 InterPro IPR000792 Transcription regulator LuxR, C-terminal
128 193 ProSiteProfiles PS50043 LuxR-type HTH domain profile.
128 193 InterPro IPR000792 Transcription regulator LuxR, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GM70
AlphaFold — — full sequence — Viewing
ColabFold KP13_02035
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.7 0.141
2 2.02 0.044