Protein profile

KP13_02036

LuxR family transcriptional regulator

Genome: KpKP13

Gene: AHE46473.1 Structure source: AlphaFold + ColabFold UniProt W8VI48
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Amino acids 279
Annotations 2
Features 20
PDB binders 0
Druggability 0.258

Overview

Basic information about this protein and its source genome.

Accession
KP13_02036
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46473.1
Status
annotated
Amino acids
279
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
62.771
DEG E-value
1.83e-96
Localization
Unknown
ColabFold pLDDT
72.56

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.258
Structure W8VI48
Pocket Pocket 17
P2Rank 0.125
Structure W8VI48
Pocket Pocket 1
ColabFold model
FPocket 0.61 · Pocket 4
P2Rank 0.061 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 54 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
186 251 ProSiteProfiles PS50043 LuxR-type HTH domain profile.
186 251 InterPro IPR000792 Transcription regulator LuxR, C-terminal
146 249 PANTHER PTHR43214 TWO-COMPONENT RESPONSE REGULATOR
146 249 InterPro IPR039420 Transcriptional regulatory protein WalR-like
193 249 CDD cd06170 LuxR_C_like
193 249 InterPro IPR000792 Transcription regulator LuxR, C-terminal
192 246 Pfam PF00196 Bacterial regulatory proteins, luxR family
192 246 InterPro IPR000792 Transcription regulator LuxR, C-terminal
223 235 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
223 235 InterPro IPR000792 Transcription regulator LuxR, C-terminal
193 207 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
193 207 InterPro IPR000792 Transcription regulator LuxR, C-terminal
207 223 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
207 223 InterPro IPR000792 Transcription regulator LuxR, C-terminal
185 248 SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators
185 248 InterPro IPR016032 Signal transduction response regulator, C-terminal effector
154 253 Gene3D G3DSA:1.10.10.10 -
154 253 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
190 247 SMART SM00421 luxrmega5
190 247 InterPro IPR000792 Transcription regulator LuxR, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_W8VI48
AlphaFold — — full sequence — Viewing
ColabFold KP13_02036
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
17 0.258

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.51 0.07