Protein profile

KP13_02037

putative HTH-type transcriptional regulator

Genome: KpKP13

Gene: AHE46474.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRB4
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Amino acids 293
Annotations 3
Features 18
PDB binders 0
Druggability 0.738

Overview

Basic information about this protein and its source genome.

Accession
KP13_02037
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46474.1
Status
annotated
Amino acids
293
Structure source
AlphaFold + ColabFold
GO
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
88.59

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.738
Structure A0A0H3GRB4
Pocket Pocket 2
P2Rank 0.142
Structure A0A0H3GRB4
Pocket Pocket 1
ColabFold model
FPocket 0.857 · Pocket 1
P2Rank 0.298 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 20 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
202 285 SMART SM00342 aracneu4
202 285 InterPro IPR018060 DNA binding HTH domain, AraC-type
254 269 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
254 269 InterPro IPR020449 Transcription regulator HTH, AraC- type
269 285 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
269 285 InterPro IPR020449 Transcription regulator HTH, AraC- type
7 104 CDD cd06999 cupin_HpaA-like_N
7 104 InterPro IPR047264 HpaA-like, N-terminal cupin domain
189 287 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
189 287 InterPro IPR018060 DNA binding HTH domain, AraC-type
181 289 Gene3D G3DSA:1.10.10.60 -
208 286 Pfam PF12833 Helix-turn-helix domain
208 286 InterPro IPR018060 DNA binding HTH domain, AraC-type
27 290 PANTHER PTHR43280 ARAC-FAMILY TRANSCRIPTIONAL REGULATOR
240 288 SUPERFAMILY SSF46689 Homeodomain-like
240 288 InterPro IPR009057 Homeobox-like domain superfamily
41 116 SUPERFAMILY SSF51182 RmlC-like cupins
41 116 InterPro IPR011051 RmlC-like cupin domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRB4
AlphaFold — — full sequence — Viewing
ColabFold KP13_02037
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.738
5 0.529
11 0.291

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.88 0.037
2 1.79 0.033
3 1.34 0.015
4 1.29 0.014
5 1.2 0.01