Protein profile

KP13_02496

5-carboxymethyl-2-hydroxymuconate Delta-isomerase

Genome: KpKP13

Gene: hpcD AHE46505.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GR74
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Amino acids 126
Annotations 2
Features 10
PDB binders 0
Druggability 0.163

Overview

Basic information about this protein and its source genome.

Accession
KP13_02496
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
hpcD AHE46505.1
Status
annotated
Amino acids
126
Structure source
AlphaFold + ColabFold
GO
GO:0019439 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring. GO:0008704 Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
97.69

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.163
Structure A0A0H3GR74
Pocket Pocket 1
P2Rank 0.059
Structure A0A0H3GR74
Pocket Pocket 1
ColabFold model
FPocket 0.387 · Pocket 4
P2Rank 0.057 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 56 / 4744 genomes with a hit
Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0019439 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.
  • GO:0008704 Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
1 126 Gene3D G3DSA:3.30.429.10 Macrophage Migration Inhibitory Factor
1 126 InterPro IPR014347 Tautomerase/MIF superfamily
1 126 PANTHER PTHR37950 4-HYDROXYPHENYLACETATE CATABOLISM PROTEIN
1 126 InterPro IPR004220 5-carboxymethyl-2-hydroxymuconate isomerase
2 114 CDD cd00580 CHMI
2 114 InterPro IPR004220 5-carboxymethyl-2-hydroxymuconate isomerase
2 125 Pfam PF02962 5-carboxymethyl-2-hydroxymuconate isomerase
2 125 InterPro IPR004220 5-carboxymethyl-2-hydroxymuconate isomerase
2 126 SUPERFAMILY SSF55331 Tautomerase/MIF
2 126 InterPro IPR014347 Tautomerase/MIF superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GR74
AlphaFold — — full sequence — Viewing
ColabFold KP13_02496
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.44 0.019