Protein profile

KP13_02500

4-hydroxyphenylacetate catabolism regulatory protein

Genome: KpKP13

Gene: AHE46509.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GHT2
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Amino acids 296
Annotations 3
Features 26
PDB binders 0
Druggability 0.077

Overview

Basic information about this protein and its source genome.

Accession
KP13_02500
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46509.1
Status
annotated
Amino acids
296
Structure source
AlphaFold + ColabFold
GO
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
84.48

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.077
Structure A0A0H3GHT2
Pocket Pocket 3
P2Rank 0.367
Structure A0A0H3GHT2
Pocket Pocket 1
ColabFold model
FPocket 0.546 · Pocket 22
P2Rank 0.88 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 48 / 4744 genomes with a hit
Normalized 0.01

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
212 290 Pfam PF12833 Helix-turn-helix domain
212 290 InterPro IPR018060 DNA binding HTH domain, AraC-type
244 291 SUPERFAMILY SSF46689 Homeodomain-like
244 291 InterPro IPR009057 Homeobox-like domain superfamily
273 289 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
273 289 InterPro IPR020449 Transcription regulator HTH, AraC- type
258 273 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
258 273 InterPro IPR020449 Transcription regulator HTH, AraC- type
243 285 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature.
243 285 InterPro IPR018062 HTH domain AraC-type, conserved site
188 293 Gene3D G3DSA:1.10.10.60 -
6 291 NCBIfam TIGR02297 4-hydroxyphenylacetate catabolism regulatory protein HpaA
6 291 InterPro IPR011983 4-hydroxyphenylacetate catabolism regulatory protein HpaA
38 99 Pfam PF07883 Cupin domain
38 99 InterPro IPR013096 Cupin 2, conserved barrel
206 289 SMART SM00342 aracneu4
206 289 InterPro IPR018060 DNA binding HTH domain, AraC-type
37 210 SUPERFAMILY SSF51182 RmlC-like cupins
37 210 InterPro IPR011051 RmlC-like cupin domain superfamily
44 292 PANTHER PTHR43280 ARAC-FAMILY TRANSCRIPTIONAL REGULATOR
15 103 CDD cd06999 cupin_HpaA-like_N
15 103 InterPro IPR047264 HpaA-like, N-terminal cupin domain
193 291 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
193 291 InterPro IPR018060 DNA binding HTH domain, AraC-type
21 103 Gene3D G3DSA:2.60.120.10 Jelly Rolls
21 103 InterPro IPR014710 RmlC-like jelly roll fold

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GHT2
AlphaFold — — full sequence — Viewing
ColabFold KP13_02500
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.44 0.259
2 2.88 0.091
3 0.65 0.001
4 0.54 0.0