Protein profile

KP13_01748

YhgA-like domain-containing protein

Genome: KpKP13

Gene: AHE46520.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GHS4
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Amino acids 300
Annotations 2
Features 5
PDB binders 0
Druggability 0.98

Overview

Basic information about this protein and its source genome.

Accession
KP13_01748
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46520.1
Status
annotated
Amino acids
300
Structure source
AlphaFold + ColabFold
GO
GO:1990238 Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks. GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
63.39
DEG E-value
1.72e-140
Localization
Cytoplasmic
ColabFold pLDDT
87.15

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.98
Structure A0A0H3GHS4
Pocket Pocket 1
P2Rank 0.331
Structure A0A0H3GHS4
Pocket Pocket 1
ColabFold model
FPocket 0.655 · Pocket 7
P2Rank 0.348 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 60 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:1990238 Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks.
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.

Sequence Features

Domain/signature hits from InterPro and related databases.

5 records
Show feature table
Start End DB Term Name
1 300 PANTHER PTHR34611 -
8 209 Pfam PF04754 Putative transposase, YhgA-like
8 209 InterPro IPR006842 Transposase (putative), YhgA-like
9 296 NCBIfam TIGR01784 Rpn family recombination-promoting nuclease/putative transposase
9 296 InterPro IPR010106 Recombination-promoting nuclease RpnA

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GHS4
AlphaFold — — full sequence — Viewing
ColabFold KP13_01748
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.98
12 0.305

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.4 0.185
2 2.5 0.069
3 1.93 0.04
4 1.57 0.024
5 1.3 0.014