Protein profile

KP13_01751

putative membrane protein

Genome: KpKP13

Gene: AHE46523.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GMQ8
Export view
Amino acids 430
Annotations 1
Features 15
PDB binders 0
Druggability 0.478

Overview

Basic information about this protein and its source genome.

Accession
KP13_01751
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46523.1
Status
annotated
Amino acids
430
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
88.75

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.478
Structure A0A0H3GMQ8
Pocket Pocket 30
P2Rank 0.056
Structure A0A0H3GMQ8
Pocket Pocket 1
ColabFold model
FPocket 0.405 · Pocket 32
P2Rank 0.042 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 72 / 4744 genomes with a hit
Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
50 66 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
31 34 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
399 421 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
3 422 PANTHER PTHR38442 INNER MEMBRANE PROTEIN-RELATED
50 69 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
67 398 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 15 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
419 430 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
399 418 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
16 30 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
49 421 Pfam PF04286 Protein of unknown function (DUF445)
49 421 InterPro IPR007383 Protein of unknown function DUF445
1 34 Phobius SIGNAL_PEPTIDE Signal peptide region
35 49 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GMQ8
AlphaFold — — full sequence — Viewing
ColabFold KP13_01751
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
30 0.478
11 0.004
4 0.0
10 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.49 0.056
2 2.0 0.036
3 1.25 0.011
4 1.14 0.008
5 0.98 0.005