Protein profile

KP13_01758

HlyD family secretion protein

Genome: KpKP13

Gene: AHE46530.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GHR6
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Amino acids 355
Annotations 0
Features 12
PDB binders 0
Druggability 0.5

Overview

Basic information about this protein and its source genome.

Accession
KP13_01758
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46530.1
Status
annotated
Amino acids
355
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
91.19

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.5
Structure A0A0H3GHR6
Pocket Pocket 1
P2Rank 0.083
Structure A0A0H3GHR6
Pocket Pocket 1
ColabFold model
FPocket 0.457 · Pocket 14
P2Rank 0.123 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 56 / 4744 genomes with a hit
Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
183 203 Coils Coil Coil
45 137 Gene3D G3DSA:2.40.50.100 -
216 334 Gene3D G3DSA:2.40.30.170 -
4 334 PANTHER PTHR30367 P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT AAEA-RELATED
45 88 Pfam PF13533 Biotin-lipoyl like
45 88 InterPro IPR039562 Membrane fusion protein, biotin-lipoyl like domain
45 249 SUPERFAMILY SSF111369 HlyD-like secretion proteins
34 355 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
12 34 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
85 119 Coils Coil Coil
12 33 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GHR6
AlphaFold — — full sequence — Viewing
ColabFold KP13_01758
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.5
29 0.034
6 0.004
5 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.1 0.083
2 1.26 0.011
3 1.14 0.008
4 1.09 0.007