Protein profile

KP13_01762

DNA helicase domain-containing protein

Genome: KpKP13

Gene: AHE46534.1 Structure source: AlphaFold + ColabFold UniProt A0A6A8EE28
Export view
Amino acids 616
Annotations 6
Features 11
PDB binders 0
Druggability 0.246

Overview

Basic information about this protein and its source genome.

Accession
KP13_01762
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46534.1
Status
annotated
Amino acids
616
Structure source
AlphaFold + ColabFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003678 Unwinding of a DNA helix, driven by ATP hydrolysis. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0043138 Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis. GO:0000725 A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
84.04

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.246
Structure A0A6A8EE28
Pocket Pocket 37
P2Rank 0.866
Structure A0A6A8EE28
Pocket Pocket 1
ColabFold model
FPocket 0.276 · Pocket 1
P2Rank 0.863 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 7 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0003678 Unwinding of a DNA helix, driven by ATP hydrolysis.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0043138 Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis.
  • GO:0000725 A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
422 615 Gene3D G3DSA:3.40.50.300 -
422 615 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
230 600 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
230 600 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
240 398 Pfam PF13245 AAA domain
353 527 PANTHER PTHR11070 UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER
353 527 InterPro IPR000212 DNA helicase, UvrD/REP type
228 410 Gene3D G3DSA:3.40.50.300 -
228 410 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
17 110 Pfam PF08378 Nuclease-related domain
17 110 InterPro IPR011528 Nuclease-related domain, NERD

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A6A8EE28
AlphaFold — — full sequence — Viewing
ColabFold KP13_01762
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
37 0.246

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.61 0.618
2 5.15 0.237
3 2.98 0.097
4 2.38 0.063
5 2.02 0.044