Protein profile

KP13_01771

HlyD family secretion protein

Genome: KpKP13

Gene: AHE46542.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GIJ7
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Amino acids 355
Annotations 2
Features 21
PDB binders 0
Druggability 0.607

Overview

Basic information about this protein and its source genome.

Accession
KP13_01771
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46542.1
Status
annotated
Amino acids
355
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
92.49

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.607
Structure A0A0H3GIJ7
Pocket Pocket 6
P2Rank 0.55
Structure A0A0H3GIJ7
Pocket Pocket 1
ColabFold model
FPocket 0.663 · Pocket 3
P2Rank 0.484 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 67 / 4744 genomes with a hit
Normalized 0.014

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
47 80 Gene3D G3DSA:2.40.50.100 -
48 95 Pfam PF13533 Biotin-lipoyl like
48 95 InterPro IPR039562 Membrane fusion protein, biotin-lipoyl like domain
40 129 SUPERFAMILY SSF111369 HlyD-like secretion proteins
214 318 Pfam PF13437 HlyD family secretion protein
150 201 Coils Coil Coil
226 324 FunFam G3DSA:2.40.30.170:FF:000013 Glycoside hydrolase family 43
118 259 SUPERFAMILY SSF111369 HlyD-like secretion proteins
9 27 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
12 354 PANTHER PTHR30438 UNCHARACTERIZED
58 78 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
327 342 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
1 8 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
7 26 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
81 112 FunFam G3DSA:1.10.287.470:FF:000008 HlyD family efflux transporter periplasmic adaptor subunit
81 119 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
114 188 FunFam G3DSA:1.10.287.470:FF:000007 HlyD family efflux transporter periplasmic adaptor subunit
227 341 Gene3D G3DSA:2.40.30.170 -
120 175 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
28 355 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
47 80 FunFam G3DSA:2.40.50.100:FF:000039 HlyD family efflux transporter periplasmic adaptor subunit

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GIJ7
AlphaFold — — full sequence — Viewing
ColabFold KP13_01771
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.607
8 0.003
2 0.001
3 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.04 0.55