Protein profile

KP13_03713

Cation efflux system protein cusF

Genome: KpKP13

Gene: cusF AHE46554.1 Structure source: AlphaFold + ColabFold UniProt A0A483R5A3
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Amino acids 110
Annotations 0
Features 12
PDB binders 0
Druggability 0.221

Overview

Basic information about this protein and its source genome.

Accession
KP13_03713
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
cusF AHE46554.1
Status
annotated
Amino acids
110
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
55.556
DEG E-value
1.6600000000000001e-37
Localization
Periplasmic
ColabFold pLDDT
82.12

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.221
Structure A0A483R5A3
Pocket Pocket 3
P2Rank
Structure A0A483R5A3
Pocket No pockets
ColabFold model
FPocket 0.329 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 41 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
19 36 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
7 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 36 Phobius SIGNAL_PEPTIDE Signal peptide region
37 110 Gene3D G3DSA:2.40.50.320 Copper binding periplasmic protein CusF
37 110 InterPro IPR042230 Copper binding periplasmic protein CusF superfamily
43 105 Pfam PF11604 Copper binding periplasmic protein CusF
43 105 InterPro IPR021647 Copper binding periplasmic protein CusF
1 19 SignalP_EUK SignalP-noTM SignalP-noTM
37 110 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 22 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 22 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A483R5A3
AlphaFold — — full sequence — Viewing
ColabFold KP13_03713
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.221