Protein profile

KP13_03718

HTH-type transcriptional regulator mlrA

Genome: KpKP13

Gene: AHE46559.1 mlrA Structure source: AlphaFold + ColabFold UniProt A0A0H3GLY1
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Amino acids 242
Annotations 3
Features 14
PDB binders 0
Druggability 0.043

Overview

Basic information about this protein and its source genome.

Accession
KP13_03718
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46559.1 mlrA
Status
annotated
Amino acids
242
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
89.5

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.043
Structure A0A0H3GLY1
Pocket Pocket 1
P2Rank 0.224
Structure A0A0H3GLY1
Pocket Pocket 1
ColabFold model
FPocket 0.123 · Pocket 1
P2Rank 0.008 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 31 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
3 70 CDD cd01104 HTH_MlrA-CarA
6 29 ProSitePatterns PS00552 MerR-type HTH domain signature.
6 29 InterPro IPR000551 MerR-type HTH domain
3 70 Pfam PF13411 MerR HTH family regulatory protein
3 70 InterPro IPR000551 MerR-type HTH domain
3 93 SUPERFAMILY SSF46955 Putative DNA-binding domain
3 93 InterPro IPR009061 Putative DNA-binding domain superfamily
1 71 ProSiteProfiles PS50937 MerR-type HTH domain profile.
1 71 InterPro IPR000551 MerR-type HTH domain
3 72 SMART SM00422 merrmega3
3 72 InterPro IPR000551 MerR-type HTH domain
1 115 Gene3D G3DSA:1.10.1660.10 -
2 119 PANTHER PTHR30204 REDOX-CYCLING DRUG-SENSING TRANSCRIPTIONAL ACTIVATOR SOXR
2 119 InterPro IPR047057 MerR transcriptional regulator

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLY1
AlphaFold — — full sequence — Viewing
ColabFold KP13_03718
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.98 0.097