Protein profile

KP13_32163

maltose-inducible porin Maltoporin

Genome: KpKP13

Gene: AHE46569.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLX3
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Amino acids 460
Annotations 3
Features 13
PDB binders 0
Druggability 0.632

Overview

Basic information about this protein and its source genome.

Accession
KP13_32163
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46569.1
Status
annotated
Amino acids
460
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034219 The process in which a carbohydrate is transported across a membrane. GO:0015288 Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
OuterMembrane
ColabFold pLDDT
87.01

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.632
Structure A0A0H3GLX3
Pocket Pocket 2
P2Rank 0.951
Structure A0A0H3GLX3
Pocket Pocket 1
ColabFold model
FPocket 0.946 · Pocket 31
P2Rank 0.95 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 50 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0034219 The process in which a carbohydrate is transported across a membrane.
  • GO:0015288 Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 25 SignalP_EUK SignalP-noTM SignalP-noTM
81 460 Gene3D G3DSA:2.40.170.10 Porin, LamB type
81 460 InterPro IPR036998 Porin, LamB-type superfamily
9 20 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region
1 25 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
81 460 SUPERFAMILY SSF56935 Porins
21 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 8 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
74 460 PANTHER PTHR38762 CRYPTIC OUTER MEMBRANE PORIN BGLH-RELATED
26 460 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
83 460 Pfam PF02264 LamB porin
83 460 InterPro IPR003192 Porin, LamB-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLX3
AlphaFold — — full sequence — Viewing
ColabFold KP13_32163
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.632
32 0.332
7 0.048
27 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 41.63 0.951
2 11.74 0.539
3 3.35 0.094
4 2.34 0.049
5 2.28 0.047