Protein profile

KP13_01207

actin-like ATPase domain-containing protein

Genome: KpKP13

Gene: AHE46574.1 Structure source: ColabFold
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Amino acids 370
Annotations 2
Features 15
PDB binders 2
Druggability 0.388

Overview

Basic information about this protein and its source genome.

Accession
KP13_01207
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46574.1
Status
annotated
Amino acids
370
Structure source
ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
32.692
Human E-value
8.4e-06
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
93.9

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.388
Structure CB_KP13_01207
Pocket Pocket 7
P2Rank 0.888
Structure CB_KP13_01207
Pocket Pocket 1
ColabFold model
FPocket 0.388 · Pocket 7
P2Rank 0.888 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 3 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
211 336 Gene3D G3DSA:3.30.420.40 -
77 210 Gene3D G3DSA:3.30.420.40 -
14 362 PANTHER PTHR18964 ROK (REPRESSOR, ORF, KINASE) FAMILY
14 362 InterPro IPR000600 ROK family
81 365 SUPERFAMILY SSF53067 Actin-like ATPase domain
81 365 InterPro IPR043129 ATPase, nucleotide binding domain
11 59 Pfam PF12802 MarR family
11 59 InterPro IPR000835 MarR-type HTH domain
127 244 CDD cd00012 NBD_sugar-kinase_HSP70_actin
10 76 Gene3D G3DSA:1.10.10.10 -
10 76 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
95 242 Pfam PF00480 ROK family
95 242 InterPro IPR000600 ROK family
12 76 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
12 76 InterPro IPR036390 Winged helix DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold KP13_01207
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.388
28 0.231
2 0.219

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.89 0.703
2 3.53 0.13
3 1.65 0.028

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

52 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
7PE
5F7Q
Q8YAF1 310.4 Da LogP 0.10 TPSA 75.6 ✓ Ro5 ✓ Clean CCOCCOCCOCCOCCOCCOCCO
PG5
5F7Q
Q8YAF1 178.2 Da LogP 0.31 TPSA 36.9 ✓ Ro5 ✓ Clean COCCOCCOCCOC

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.