Protein profile

KP13_01344

transposase for insertion sequence element IS1222

Genome: KpKP13

Gene: AHE46592.1 Structure source: ColabFold
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Amino acids 165
Annotations 2
Features 9
PDB binders 0
Druggability 0.239

Overview

Basic information about this protein and its source genome.

Accession
KP13_01344
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46592.1
Status
annotated
Amino acids
165
Structure source
ColabFold
GO
GO:0003676 Binding to a nucleic acid. GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
67.105
DEG E-value
3.63e-77
Localization
Cytoplasmic
ColabFold pLDDT
90.22

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.239
Structure CB_KP13_01344
Pocket Pocket 1
P2Rank 0.214
Structure CB_KP13_01344
Pocket Pocket 1
ColabFold model
FPocket 0.239 · Pocket 1
P2Rank 0.214 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 24 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003676 Binding to a nucleic acid.
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
1 148 SUPERFAMILY SSF53098 Ribonuclease H-like
1 148 InterPro IPR012337 Ribonuclease H-like superfamily
1 157 PANTHER PTHR47515 LOW CALCIUM RESPONSE LOCUS PROTEIN T
78 144 Pfam PF13683 Integrase core domain
78 144 InterPro IPR001584 Integrase, catalytic core
1 159 Gene3D G3DSA:3.30.420.10 -
1 159 InterPro IPR036397 Ribonuclease H superfamily
1 152 ProSiteProfiles PS50994 Integrase catalytic domain profile.
1 152 InterPro IPR001584 Integrase, catalytic core

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold KP13_01344
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.239

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.43 0.124
2 1.87 0.037
3 1.49 0.021
4 0.85 0.003