Protein profile

KP13_01342

5-methylcytosine restriction system component protein

Genome: KpKP13

Gene: AHE46594.1 Structure source: AlphaFold + ColabFold UniProt A0A6A8END0
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Amino acids 453
Annotations 1
Features 4
PDB binders 0
Druggability 0.958

Overview

Basic information about this protein and its source genome.

Accession
KP13_01342
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46594.1
Status
annotated
Amino acids
453
Structure source
AlphaFold + ColabFold
GO
GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
84.48

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.958
Structure A0A6A8END0
Pocket Pocket 1
P2Rank 0.438
Structure A0A6A8END0
Pocket Pocket 1
ColabFold model
FPocket 0.261 · Pocket 26
P2Rank 0.072 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 2 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.

Sequence Features

Domain/signature hits from InterPro and related databases.

4 records
Show feature table
Start End DB Term Name
7 418 PANTHER PTHR38733 PROTEIN MCRC
7 418 InterPro IPR019292 Type IV methyl-directed restriction enzyme EcoKMcrBC
59 383 Pfam PF10117 McrBC 5-methylcytosine restriction system component
59 383 InterPro IPR019292 Type IV methyl-directed restriction enzyme EcoKMcrBC

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A6A8END0
AlphaFold — — full sequence — Viewing
ColabFold KP13_01342
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.958