Protein profile

KP13_31615

Insertion element IS3 family

Genome: KpKP13

Gene: AHE46595.1 Structure source: ColabFold
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Amino acids 231
Annotations 2
Features 13
PDB binders 0
Druggability 0.24

Overview

Basic information about this protein and its source genome.

Accession
KP13_31615
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46595.1
Status
annotated
Amino acids
231
Structure source
ColabFold
GO
GO:0003676 Binding to a nucleic acid. GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
42.358
DEG E-value
2.74e-61
Localization
Cytoplasmic
ColabFold pLDDT
86.51

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.24
Structure CB_KP13_31615
Pocket Pocket 12
P2Rank 0.102
Structure CB_KP13_31615
Pocket Pocket 1
ColabFold model
FPocket 0.24 · Pocket 12
P2Rank 0.102 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 6 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003676 Binding to a nucleic acid.
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
2 229 PANTHER PTHR47515 LOW CALCIUM RESPONSE LOCUS PROTEIN T
2 221 NCBIfam NF033516 IS3 family transposase
59 226 ProSiteProfiles PS50994 Integrase catalytic domain profile.
59 226 InterPro IPR001584 Integrase, catalytic core
152 218 Pfam PF13683 Integrase core domain
152 218 InterPro IPR001584 Integrase, catalytic core
60 222 SUPERFAMILY SSF53098 Ribonuclease H-like
60 222 InterPro IPR012337 Ribonuclease H-like superfamily
190 210 Coils Coil Coil
2 51 Pfam PF13276 HTH-like domain
2 51 InterPro IPR025948 HTH-like domain
65 229 Gene3D G3DSA:3.30.420.10 -
65 229 InterPro IPR036397 Ribonuclease H superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold KP13_31615
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.24
20 0.204

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.61 0.026
2 1.61 0.026