Protein profile

KP13_01326

putative sn-glycerol-3-phosphate transport system permease protein

Genome: KpKP13

Gene: AHE46609.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQY6
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Amino acids 294
Annotations 3
Features 30
PDB binders 0
Druggability 0.881

Overview

Basic information about this protein and its source genome.

Accession
KP13_01326
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46609.1
Status
annotated
Amino acids
294
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.66

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.881
Structure A0A0H3GQY6
Pocket Pocket 4
P2Rank 0.072
Structure A0A0H3GQY6
Pocket Pocket 1
ColabFold model
FPocket 0.818 · Pocket 3
P2Rank 0.248 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 15 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records
Show feature table
Start End DB Term Name
96 106 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
227 265 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
83 281 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
83 281 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
53 281 SUPERFAMILY SSF161098 MetI-like
53 281 InterPro IPR035906 MetI-like superfamily
107 134 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
97 255 CDD cd06261 TM_PBP2
97 255 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
287 294 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
156 178 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
69 282 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
69 282 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
12 30 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
181 200 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
201 226 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
207 229 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
49 290 Gene3D G3DSA:1.10.3720.10 -
49 290 InterPro IPR035906 MetI-like superfamily
135 153 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
9 31 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
73 95 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
266 286 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
154 180 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
4 289 PANTHER PTHR43227 BLL4140 PROTEIN
264 286 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
107 129 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
73 95 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
31 72 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQY6
AlphaFold — — full sequence — Viewing
ColabFold KP13_01326
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.881
5 0.833
21 0.265

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.93 0.04
2 1.84 0.035
3 1.38 0.017
4 1.27 0.013