Protein profile

KP13_01325

putative sn-glycerol-3-phosphate transport system permease protein

Genome: KpKP13

Gene: AHE46610.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GIE8
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Amino acids 295
Annotations 3
Features 30
PDB binders 0
Druggability 0.971

Overview

Basic information about this protein and its source genome.

Accession
KP13_01325
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46610.1
Status
annotated
Amino acids
295
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
85.74

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.971
Structure A0A0H3GIE8
Pocket Pocket 2
P2Rank 0.546
Structure A0A0H3GIE8
Pocket Pocket 1
ColabFold model
FPocket 0.974 · Pocket 17
P2Rank 0.565 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 16 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records
Show feature table
Start End DB Term Name
184 203 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
29 51 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
52 88 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
89 114 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 28 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
144 162 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
90 281 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
90 281 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
163 183 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
226 259 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
21 287 Gene3D G3DSA:1.10.3720.10 -
21 287 InterPro IPR035906 MetI-like superfamily
110 282 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
110 282 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
95 117 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
29 51 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
126 148 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
92 270 CDD cd06261 TM_PBP2
92 270 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
260 281 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
204 225 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
201 223 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
115 125 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
152 174 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
26 295 PANTHER PTHR43744 ABC TRANSPORTER PERMEASE PROTEIN MG189-RELATED-RELATED
126 143 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
27 295 SUPERFAMILY SSF161098 MetI-like
27 295 InterPro IPR035906 MetI-like superfamily
282 295 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
259 281 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GIE8
AlphaFold — — full sequence — Viewing
ColabFold KP13_01325
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.971

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.24 0.679
2 6.51 0.329
3 3.68 0.139
4 2.93 0.094
5 1.63 0.026