Protein profile

KP13_01321

Inosose dehydratase

Genome: KpKP13

Gene: iolE AHE46614.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQY1
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Amino acids 299
Annotations 5
Features 10
PDB binders 0
Druggability 0.589

Overview

Basic information about this protein and its source genome.

Accession
KP13_01321
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
iolE AHE46614.1
Status
annotated
Amino acids
299
Structure source
AlphaFold + ColabFold
EC
4.2.1.44
GO
GO:0019310 The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. GO:0050114 Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O. GO:0030145 Binding to a manganese ion (Mn). GO:0016853 Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
97.52

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.589
Structure A0A0H3GQY1
Pocket Pocket 1
P2Rank 0.832
Structure A0A0H3GQY1
Pocket Pocket 1
ColabFold model
FPocket 0.463 · Pocket 1
P2Rank 0.857 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 210 / 4744 genomes with a hit
Normalized 0.044

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0019310 The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms.
  • GO:0050114 Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O.
  • GO:0030145 Binding to a manganese ion (Mn).
  • GO:0016853 Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
5 296 NCBIfam TIGR04379 myo-inosose-2 dehydratase
5 296 InterPro IPR030823 IolE/MocC family
1 299 Hamap MF_01672 Inosose dehydratase [iolE].
1 299 InterPro IPR023952 Inosose dehydratase
37 294 Pfam PF01261 Xylose isomerase-like TIM barrel
37 294 InterPro IPR013022 Xylose isomerase-like, TIM barrel domain
2 295 PANTHER PTHR12110 HYDROXYPYRUVATE ISOMERASE
1 296 Gene3D G3DSA:3.20.20.150 -
7 296 SUPERFAMILY SSF51658 Xylose isomerase-like
7 296 InterPro IPR036237 Xylose isomerase-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQY1
AlphaFold — — full sequence — Viewing
ColabFold KP13_01321
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.589
6 0.005
13 0.001
2 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 22.82 0.832
2 2.25 0.045
3 1.39 0.014
4 1.11 0.007