Protein profile

KP13_01315

putative HTH-type transcriptional regulator

Genome: KpKP13

Gene: AHE46620.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GIE0
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Amino acids 307
Annotations 5
Features 19
PDB binders 1
Druggability 0.62

Overview

Basic information about this protein and its source genome.

Accession
KP13_01315
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46620.1
Status
annotated
Amino acids
307
Structure source
AlphaFold + ColabFold
GO
GO:1901135 The chemical reactions and pathways involving carbohydrate derivative. GO:0097367 Binding to a carbohydrate derivative. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
78.832
DEG E-value
1.93e-161
Localization
Cytoplasmic
ColabFold pLDDT
85.87

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.62
Structure A0A0H3GIE0
Pocket Pocket 23
P2Rank 0.072
Structure A0A0H3GIE0
Pocket Pocket 1
ColabFold model
FPocket 0.847 · Pocket 1
P2Rank 0.151 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 62 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:1901135 The chemical reactions and pathways involving carbohydrate derivative.
  • GO:0097367 Binding to a carbohydrate derivative.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
33 302 PANTHER PTHR30514 GLUCOKINASE
33 302 InterPro IPR047640 HTH-type transcriptional regulator RpiR-like
166 295 Pfam PF01380 SIS domain
166 295 InterPro IPR001347 SIS domain
133 294 SUPERFAMILY SSF53697 SIS domain
133 294 InterPro IPR046348 SIS domain superfamily
162 301 ProSiteProfiles PS51464 SIS domain profile.
162 301 InterPro IPR001347 SIS domain
34 104 Pfam PF01418 Helix-turn-helix domain, rpiR family
34 104 InterPro IPR000281 Helix-turn-helix protein RpiR
35 108 SUPERFAMILY SSF46689 Homeodomain-like
35 108 InterPro IPR009057 Homeobox-like domain superfamily
31 107 ProSiteProfiles PS51071 RpiR-type HTH domain profile.
31 107 InterPro IPR000281 Helix-turn-helix protein RpiR
133 307 Gene3D G3DSA:3.40.50.10490 -
30 105 Gene3D G3DSA:1.10.10.10 -
30 105 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
157 292 CDD cd05013 SIS_RpiR
157 292 InterPro IPR035472 RpiR-like, SIS domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GIE0
AlphaFold — — full sequence — Viewing
ColabFold KP13_01315
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.536
13 0.0
18 0.0
20 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.85 0.072
2 1.72 0.025
3 1.51 0.018
4 1.38 0.014
5 1.21 0.01

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

10 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
MXE
3IWF
A0A0H2VHQ2 76.1 Da LogP -0.37 TPSA 29.5 ✓ Ro5 ✓ Clean COCCO

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.