Protein profile

KP13_01312

5-deoxy-glucuronate isomerase

Genome: KpKP13

Gene: iolB AHE46624.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GMJ5
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Amino acids 269
Annotations 3
Features 14
PDB binders 0
Druggability 0.949

Overview

Basic information about this protein and its source genome.

Accession
KP13_01312
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
iolB AHE46624.1
Status
annotated
Amino acids
269
Structure source
AlphaFold + ColabFold
GO
GO:0019310 The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. GO:0008880 Catalysis of the reaction: D-glucuronate = D-fructuronate. Also converts D-galacturonate to D-tagaturonate. GO:0016861 Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
97.57

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.949
Structure A0A0H3GMJ5
Pocket Pocket 1
P2Rank 0.883
Structure A0A0H3GMJ5
Pocket Pocket 1
ColabFold model
FPocket 0.743 · Pocket 1
P2Rank 0.882 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 76 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0019310 The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms.
  • GO:0008880 Catalysis of the reaction: D-glucuronate = D-fructuronate. Also converts D-galacturonate to D-tagaturonate.
  • GO:0016861 Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
14 249 SUPERFAMILY SSF51182 RmlC-like cupins
14 249 InterPro IPR011051 RmlC-like cupin domain superfamily
120 267 Gene3D G3DSA:2.60.120.10 Jelly Rolls
120 267 InterPro IPR014710 RmlC-like jelly roll fold
11 119 Gene3D G3DSA:2.60.120.10 Jelly Rolls
11 119 InterPro IPR014710 RmlC-like jelly roll fold
5 260 Pfam PF04962 KduI/IolB family
5 260 InterPro IPR021120 KduI/IolB isomerase
1 266 PIRSF PIRSF036628 IolB
1 266 InterPro IPR024203 5-deoxy-glucuronate isomerase, IolB
7 267 PANTHER PTHR39193 5-DEOXY-GLUCURONATE ISOMERASE
7 267 InterPro IPR024203 5-deoxy-glucuronate isomerase, IolB
14 260 NCBIfam TIGR04378 5-deoxy-glucuronate isomerase
14 260 InterPro IPR024203 5-deoxy-glucuronate isomerase, IolB

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GMJ5
AlphaFold — — full sequence — Viewing
ColabFold KP13_01312
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.949

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 17.57 0.804
2 2.7 0.08
3 1.25 0.012