Protein profile

KP13_01310

Sugar epimerase domain-containing protein

Genome: KpKP13

Gene: AHE46626.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GHJ9
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Amino acids 273
Annotations 1
Features 8
PDB binders 0
Druggability 0.302

Overview

Basic information about this protein and its source genome.

Accession
KP13_01310
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46626.1
Status
annotated
Amino acids
273
Structure source
AlphaFold + ColabFold
GO
GO:0016853 Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
97.51

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.302
Structure A0A0H3GHJ9
Pocket Pocket 13
P2Rank 0.695
Structure A0A0H3GHJ9
Pocket Pocket 1
ColabFold model
FPocket 0.472 · Pocket 5
P2Rank 0.791 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 32 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016853 Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
1 273 PIRSF PIRSF036778 UCP036778
1 273 InterPro IPR014621 Uncharacterised conserved protein UCP036778, sugar epimerase-type
2 268 SUPERFAMILY SSF51658 Xylose isomerase-like
2 268 InterPro IPR036237 Xylose isomerase-like superfamily
24 263 Pfam PF01261 Xylose isomerase-like TIM barrel
24 263 InterPro IPR013022 Xylose isomerase-like, TIM barrel domain
1 269 Gene3D G3DSA:3.20.20.150 -
4 263 PANTHER PTHR43489 ISOMERASE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GHJ9
AlphaFold — — full sequence — Viewing
ColabFold KP13_01310
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
13 0.302
2 0.235

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.93 0.668
2 1.59 0.025
3 1.13 0.008