Protein profile

KP13_01309

hypothetical protein

Genome: KpKP13

Gene: AHE46627.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQX2
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Amino acids 500
Annotations 0
Features 12
PDB binders 0
Druggability 0.603

Overview

Basic information about this protein and its source genome.

Accession
KP13_01309
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46627.1
Status
annotated
Amino acids
500
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
47.073
DEG E-value
6.09e-123
Localization
CytoplasmicMembrane
ColabFold pLDDT
85.86

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.603
Structure A0A0H3GQX2
Pocket Pocket 1
P2Rank 0.251
Structure A0A0H3GQX2
Pocket Pocket 1
ColabFold model
FPocket 0.642 · Pocket 37
P2Rank 0.264 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 367 / 4744 genomes with a hit
Normalized 0.077

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
202 380 Gene3D G3DSA:3.40.50.300 -
202 380 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
425 439 MobiDBLite mobidb-lite consensus disorder prediction
198 319 CDD cd01127 TrwB_TraG_TraD_VirD4
9 90 Gene3D G3DSA:3.40.50.300 -
9 90 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
425 445 MobiDBLite mobidb-lite consensus disorder prediction
13 471 PANTHER PTHR30121 UNCHARACTERIZED PROTEIN YJGR-RELATED
5 500 Pfam PF05872 Helicase HerA-like C-terminal
5 500 InterPro IPR033186 Helicase HerA-like C-terminal
9 369 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
9 369 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQX2
AlphaFold — — full sequence — Viewing
ColabFold KP13_01309
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
18 0.417
4 0.287
11 0.003
2 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.1 0.251
2 3.54 0.104
3 3.4 0.097
4 1.17 0.009