Protein profile

KP13_01304

DNA polymerase III subunit chi

Genome: KpKP13

Gene: AHE46630.1 holC Structure source: AlphaFold + ColabFold UniProt A0A0H3GHJ5
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Amino acids 147
Annotations 4
Features 9
PDB binders 0
Druggability 0.143

Overview

Basic information about this protein and its source genome.

Accession
KP13_01304
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46630.1 holC
Status
annotated
Amino acids
147
Structure source
AlphaFold + ColabFold
GO
GO:0006260 The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0003887 Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0032298 Any process that activates or increases the frequency, rate or extent of initiation of DNA-dependent DNA replication.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
91.156
DEG E-value
1.19e-100
Localization
Cytoplasmic
ColabFold pLDDT
95.23

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.143
Structure A0A0H3GHJ5
Pocket Pocket 1
P2Rank 0.234
Structure A0A0H3GHJ5
Pocket Pocket 1
ColabFold model
FPocket 0.477 · Pocket 4
P2Rank 0.169 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 133 / 4744 genomes with a hit
Normalized 0.028

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0006260 The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
  • GO:0003887 Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0032298 Any process that activates or increases the frequency, rate or extent of initiation of DNA-dependent DNA replication.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
1 147 FunFam G3DSA:3.40.50.10110:FF:000001 DNA polymerase III subunit chi
1 141 Pfam PF04364 DNA polymerase III chi subunit, HolC
1 141 InterPro IPR007459 DNA polymerase III chi subunit, HolC
1 147 Gene3D G3DSA:3.40.50.10110 DNA polymerase III subunit chi
1 147 InterPro IPR036768 DNA polymerase III subunit chi superfamily
1 147 PANTHER PTHR38767 DNA POLYMERASE III SUBUNIT CHI
1 147 InterPro IPR007459 DNA polymerase III chi subunit, HolC
1 145 SUPERFAMILY SSF102400 DNA polymerase III chi subunit
1 145 InterPro IPR036768 DNA polymerase III subunit chi superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GHJ5
AlphaFold — — full sequence — Viewing
ColabFold KP13_01304
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.16 0.108
2 0.97 0.005