Protein profile

KP13_01302

GCN5-related N-acetyltransferase

Genome: KpKP13

Gene: AHE46632.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GID0
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Amino acids 158
Annotations 2
Features 8
PDB binders 0
Druggability 0.527

Overview

Basic information about this protein and its source genome.

Accession
KP13_01302
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46632.1
Status
annotated
Amino acids
158
Structure source
AlphaFold + ColabFold
GO
GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0008080 Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
40.0
Human E-value
3.29e-10
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
87.261
DEG E-value
1.45e-94
Localization
Cytoplasmic
ColabFold pLDDT
90.19

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.527
Structure A0A0H3GID0
Pocket Pocket 2
P2Rank 0.944
Structure A0A0H3GID0
Pocket Pocket 1
ColabFold model
FPocket 0.461 · Pocket 1
P2Rank 0.935 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 122 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
  • GO:0008080 Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
1 158 ProSiteProfiles PS51186 Gcn5-related N-acetyltransferase (GNAT) domain profile.
1 158 InterPro IPR000182 GNAT domain
34 154 PANTHER PTHR13947 GNAT FAMILY N-ACETYLTRANSFERASE
4 141 Gene3D G3DSA:3.40.630.30 -
1 158 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
1 158 InterPro IPR016181 Acyl-CoA N-acyltransferase
36 135 Pfam PF00583 Acetyltransferase (GNAT) family
36 135 InterPro IPR000182 GNAT domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GID0
AlphaFold — — full sequence — Viewing
ColabFold KP13_01302
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.527
1 0.005
3 0.0
5 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 39.38 0.944