Protein profile

KP13_01296

putative amidohydrolase

Genome: KpKP13

Gene: AHE46638.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GMI4
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Amino acids 521
Annotations 1
Features 11
PDB binders 0
Druggability 0.481

Overview

Basic information about this protein and its source genome.

Accession
KP13_01296
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46638.1
Status
annotated
Amino acids
521
Structure source
AlphaFold + ColabFold
GO
GO:0016810 Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
96.31

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.481
Structure A0A0H3GMI4
Pocket Pocket 2
P2Rank 0.929
Structure A0A0H3GMI4
Pocket Pocket 1
ColabFold model
FPocket 0.771 · Pocket 1
P2Rank 0.907 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 7 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016810 Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
84 181 Gene3D G3DSA:3.10.310.70 -
3 519 SUPERFAMILY SSF51338 Composite domain of metallo-dependent hydrolases
3 519 InterPro IPR011059 Metal-dependent hydrolase, composite domain superfamily
66 477 Gene3D G3DSA:3.20.20.140 -
65 478 SUPERFAMILY SSF51556 Metallo-dependent hydrolases
65 478 InterPro IPR032466 Metal-dependent hydrolase
4 519 PANTHER PTHR22642 IMIDAZOLONEPROPIONASE
55 517 Pfam PF07969 Amidohydrolase family
55 517 InterPro IPR013108 Amidohydrolase 3
15 493 Gene3D G3DSA:2.30.40.10 Urease, subunit C, domain 1
15 493 InterPro IPR011059 Metal-dependent hydrolase, composite domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GMI4
AlphaFold — — full sequence — Viewing
ColabFold KP13_01296
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.207
24 0.003
3 0.002
22 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 34.76 0.929
2 4.63 0.166
3 3.22 0.088
4 1.74 0.026
5 1.62 0.021