Protein profile

KP13_01275

Antitoxin RelB

Genome: KpKP13

Gene: AHE46659.1 relB Structure source: AlphaFold + ColabFold UniProt A0A0H3GLP0
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Amino acids 80
Annotations 3
Features 8
PDB binders 0
Druggability 0.152

Overview

Basic information about this protein and its source genome.

Accession
KP13_01275
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46659.1 relB
Status
annotated
Amino acids
80
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006351 The synthesis of an RNA transcript from a DNA template.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
87.12

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.152
Structure A0A0H3GLP0
Pocket Pocket 4
P2Rank
Structure A0A0H3GLP0
Pocket No pockets
ColabFold model
FPocket 0.098 · Pocket 4
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 33 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0006351 The synthesis of an RNA transcript from a DNA template.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
1 69 Pfam PF04221 RelB antitoxin
1 69 InterPro IPR007337 RelB antitoxin/Antitoxin DinJ
1 80 Gene3D G3DSA:1.10.1220.10 -
1 80 InterPro IPR013321 Arc-type ribbon-helix-helix
1 80 NCBIfam TIGR02384 type II toxin-antitoxin system RelB/DinJ family antitoxin
1 80 InterPro IPR007337 RelB antitoxin/Antitoxin DinJ
1 64 PANTHER PTHR38781 ANTITOXIN DINJ-RELATED
1 64 InterPro IPR007337 RelB antitoxin/Antitoxin DinJ

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

No pockets are loaded yet for the displayed AlphaFold model AF_A0A0H3GLP0 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLP0
AlphaFold — — full sequence — Viewing
ColabFold KP13_01275
ColabFold — — full sequence — Loaded