Protein profile

KP13_01270

metal-dependent hydrolase

Genome: KpKP13

Gene: AHE46664.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLN5
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Amino acids 377
Annotations 4
Features 16
PDB binders 0
Druggability 0.166

Overview

Basic information about this protein and its source genome.

Accession
KP13_01270
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46664.1
Status
annotated
Amino acids
377
Structure source
AlphaFold + ColabFold
GO
GO:0019213 Catalysis of the hydrolysis of an acetyl group from a substrate molecule. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0016810 Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
97.95

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.166
Structure A0A0H3GLN5
Pocket Pocket 2
P2Rank 0.843
Structure A0A0H3GLN5
Pocket Pocket 1
ColabFold model
FPocket 0.315 · Pocket 4
P2Rank 0.675 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 96 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0019213 Catalysis of the hydrolysis of an acetyl group from a substrate molecule.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0016810 Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
51 316 SUPERFAMILY SSF51556 Metallo-dependent hydrolases
51 316 InterPro IPR032466 Metal-dependent hydrolase
51 316 Gene3D G3DSA:3.20.20.140 -
2 376 PANTHER PTHR42717 DIHYDROOROTASE-RELATED
2 376 InterPro IPR020043 Deacetylase Atu3266-like
47 331 Pfam PF01979 Amidohydrolase family
47 331 InterPro IPR006680 Amidohydrolase-related
18 354 CDD cd01307 Met_dep_hydrolase_B
1 375 PIRSF PIRSF039004 ADE_EF_0837
1 375 InterPro IPR020043 Deacetylase Atu3266-like
1 59 SUPERFAMILY SSF51338 Composite domain of metallo-dependent hydrolases
1 59 InterPro IPR011059 Metal-dependent hydrolase, composite domain superfamily
6 362 Gene3D G3DSA:2.30.40.10 Urease, subunit C, domain 1
6 362 InterPro IPR011059 Metal-dependent hydrolase, composite domain superfamily
3 364 NCBIfam TIGR03583 dihydroorotase
3 364 InterPro IPR047601 Deacetylase EF_0837-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLN5
AlphaFold — — full sequence — Viewing
ColabFold KP13_01270
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 16.5 0.78
2 1.66 0.028