Protein profile

KP13_01268

hypothetical protein

Genome: KpKP13

Gene: AHE46666.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQT1
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Amino acids 258
Annotations 0
Features 22
PDB binders 0
Druggability 0.799

Overview

Basic information about this protein and its source genome.

Accession
KP13_01268
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46666.1
Status
annotated
Amino acids
258
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
87.97

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.799
Structure A0A0H3GQT1
Pocket Pocket 6
P2Rank 0.138
Structure A0A0H3GQT1
Pocket Pocket 1
ColabFold model
FPocket 0.921 · Pocket 10
P2Rank 0.339 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 130 / 4744 genomes with a hit
Normalized 0.027

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
172 199 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
211 229 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
230 258 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
177 199 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 24 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
214 232 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
200 210 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
6 28 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
55 77 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
110 132 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
111 133 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 258 NCBIfam TIGR03580 conserved hypothetical protein EF_0832/AHA_3913
2 258 InterPro IPR020042 Protein of unknown function DUF4311
166 171 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
144 165 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
143 165 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
133 143 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
25 236 Pfam PF14188 Domain of unknown function (DUF4311)
25 236 InterPro IPR020042 Protein of unknown function DUF4311
29 109 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQT1
AlphaFold — — full sequence — Viewing
ColabFold KP13_01268
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.799
15 0.411
8 0.317

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.5 0.192
2 3.56 0.132
3 2.2 0.053
4 1.71 0.03
5 1.51 0.022