Protein profile

KP13_03528

putative transposase InsK for insertion sequence element IS150

Genome: KpKP13

Gene: insK AHE46674.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRH9
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Amino acids 252
Annotations 2
Features 14
PDB binders 0
Druggability 0.019

Overview

Basic information about this protein and its source genome.

Accession
KP13_03528
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
insK AHE46674.1
Status
annotated
Amino acids
252
Structure source
AlphaFold + ColabFold
GO
GO:0003676 Binding to a nucleic acid. GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
51.639
DEG E-value
2.5999999999999996e-90
Localization
Unknown
ColabFold pLDDT
88.33

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.019
Structure A0A0H3GRH9
Pocket Pocket 2
P2Rank 0.236
Structure A0A0H3GRH9
Pocket Pocket 1
ColabFold model
FPocket 0.214 · Pocket 10
P2Rank 0.644 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 195 / 4744 genomes with a hit
Normalized 0.041

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003676 Binding to a nucleic acid.
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
84 243 SUPERFAMILY SSF53098 Ribonuclease H-like
84 243 InterPro IPR012337 Ribonuclease H-like superfamily
75 249 ProSiteProfiles PS50994 Integrase catalytic domain profile.
75 249 InterPro IPR001584 Integrase, catalytic core
194 249 Pfam PF13333 Integrase core domain
194 249 InterPro IPR001584 Integrase, catalytic core
8 245 NCBIfam NF033516 IS3 family transposase
13 66 Pfam PF13276 HTH-like domain
13 66 InterPro IPR025948 HTH-like domain
90 187 Pfam PF00665 Integrase core domain
90 187 InterPro IPR001584 Integrase, catalytic core
12 247 PANTHER PTHR46889 TRANSPOSASE INSF FOR INSERTION SEQUENCE IS3B-RELATED
85 245 Gene3D G3DSA:3.30.420.10 -
85 245 InterPro IPR036397 Ribonuclease H superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRH9
AlphaFold — — full sequence — Viewing
ColabFold KP13_03528
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.76 0.145
2 2.41 0.065
3 2.13 0.049