Protein profile

KP13_01259

hypothetical protein

Genome: KpKP13

Gene: AHE46678.1 Structure source: Experimental + ColabFold UniProt A6THE6
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Amino acids 402
Annotations 1
Features 13
PDB binders 0
Druggability 0.741

Overview

Basic information about this protein and its source genome.

Accession
KP13_01259
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46678.1
Status
annotated
Amino acids
402
Structure source
Experimental + ColabFold
GO
GO:0030246 Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
95.71

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.741
Structure 3TY1
Pocket Pocket 1
P2Rank 0.834
Structure 3TY1
Pocket Pocket 1
ColabFold model
FPocket 0.649 · Pocket 15
P2Rank 0.848 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 48 / 4744 genomes with a hit
Normalized 0.01

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0030246 Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
376 396 Coils Coil Coil
16 20 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 20 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 20 Phobius SIGNAL_PEPTIDE Signal peptide region
19 402 Gene3D G3DSA:2.70.98.10 -
19 402 InterPro IPR014718 Glycoside hydrolase-type carbohydrate-binding
1 20 SignalP_EUK SignalP-noTM SignalP-noTM
79 366 CDD cd09023 Aldose_epim_Ec_c4013
21 402 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
4 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
63 368 Pfam PF14486 Domain of unknown function (DUF4432)
63 368 InterPro IPR027839 Protein of unknown function DUF4432

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3TY1
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Viewing
ColabFold KP13_01259
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.827
3 0.674
2 0.582

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 19.69 0.843
2 16.51 0.78
3 15.85 0.763
4 13.34 0.683
5 3.4 0.122