Protein profile

KP13_01242

Lactose permease

Genome: KpKP13

Gene: AHE46694.1 Structure source: AlphaFold + ColabFold UniProt A0A9J6S0U4
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Amino acids 410
Annotations 3
Features 63
PDB binders 0
Druggability 0.173

Overview

Basic information about this protein and its source genome.

Accession
KP13_01242
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46694.1
Status
annotated
Amino acids
410
Structure source
AlphaFold + ColabFold
GO
GO:0008643 The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005351 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
42.593
DEG E-value
7.29e-106
Localization
CytoplasmicMembrane
ColabFold pLDDT
83.04

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.173
Structure A0A9J6S0U4
Pocket Pocket 26
P2Rank 0.959
Structure A0A9J6S0U4
Pocket Pocket 1
ColabFold model
FPocket 0.762 · Pocket 15
P2Rank 0.974 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 9 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0008643 The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005351 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in).

Sequence Features

Domain/signature hits from InterPro and related databases.

63 records
Show feature table
Start End DB Term Name
2 194 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
2 194 InterPro IPR036259 MFS transporter superfamily
34 44 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
185 217 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
202 407 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
202 407 InterPro IPR036259 MFS transporter superfamily
345 369 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
162 166 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
220 242 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
66 76 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
144 163 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
98 102 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
313 333 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
370 374 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
167 184 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
44 66 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 399 SUPERFAMILY SSF103473 MFS general substrate transporter
5 399 InterPro IPR036259 MFS transporter superfamily
218 236 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
237 255 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4 402 Pfam PF01306 LacY proton/sugar symporter
4 402 InterPro IPR000576 LacY/RafB permease family
256 275 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
334 344 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
129 139 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
45 65 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
4 400 PANTHER PTHR23522 BLL5896 PROTEIN
77 97 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
286 308 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
287 307 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
308 312 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
328 350 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
210 238 PRINTS PR00174 LacY proton/sugar symporter family signature
210 238 InterPro IPR000576 LacY/RafB permease family
256 277 PRINTS PR00174 LacY proton/sugar symporter family signature
256 277 InterPro IPR000576 LacY/RafB permease family
280 306 PRINTS PR00174 LacY proton/sugar symporter family signature
280 306 InterPro IPR000576 LacY/RafB permease family
342 362 PRINTS PR00174 LacY proton/sugar symporter family signature
342 362 InterPro IPR000576 LacY/RafB permease family
144 162 PRINTS PR00174 LacY proton/sugar symporter family signature
144 162 InterPro IPR000576 LacY/RafB permease family
102 124 PRINTS PR00174 LacY proton/sugar symporter family signature
102 124 InterPro IPR000576 LacY/RafB permease family
67 96 PRINTS PR00174 LacY proton/sugar symporter family signature
67 96 InterPro IPR000576 LacY/RafB permease family
311 330 PRINTS PR00174 LacY proton/sugar symporter family signature
311 330 InterPro IPR000576 LacY/RafB permease family
167 184 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
257 279 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
102 124 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
276 286 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
397 410 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
75 97 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
103 128 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
375 396 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
140 161 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
5 396 NCBIfam TIGR00882 oligosaccharide MFS transporter
5 396 InterPro IPR000576 LacY/RafB permease family
374 396 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
12 33 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A9J6S0U4
AlphaFold — — full sequence — Viewing
ColabFold KP13_01242
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 30.47 0.934
2 2.7 0.08
3 1.7 0.03
4 1.49 0.021
5 0.94 0.004