Protein profile

KP13_01241

Glycosyl hydrolase 42 family protein

Genome: KpKP13

Gene: AHE46695.1 Structure source: AlphaFold + ColabFold UniProt A0A6A8EF82
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Amino acids 669
Annotations 5
Features 16
PDB binders 0
Druggability 0.479

Overview

Basic information about this protein and its source genome.

Accession
KP13_01241
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46695.1
Status
annotated
Amino acids
669
Structure source
AlphaFold + ColabFold
EC
3.2.1.23
GO
GO:0004565 Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0009341 A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
97.66

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.479
Structure A0A6A8EF82
Pocket Pocket 6
P2Rank 0.882
Structure A0A6A8EF82
Pocket Pocket 1
ColabFold model
FPocket 0.635 · Pocket 4
P2Rank 0.869 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 45 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0004565 Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0009341 A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
3 650 PANTHER PTHR36447 BETA-GALACTOSIDASE GANA
3 650 InterPro IPR003476 Glycoside hydrolase, family 42
10 376 Pfam PF02449 Beta-galactosidase
10 376 InterPro IPR013529 Glycoside hydrolase, family 42, N-terminal
390 598 Pfam PF08532 Beta-galactosidase trimerisation domain
390 598 InterPro IPR013738 Beta-galactosidase trimerisation
388 598 SUPERFAMILY SSF52317 Class I glutamine amidotransferase-like
388 598 InterPro IPR029062 Class I glutamine amidotransferase-like
1 382 Gene3D G3DSA:3.20.20.80 Glycosidases
5 379 SUPERFAMILY SSF51445 (Trans)glycosidases
5 379 InterPro IPR017853 Glycoside hydrolase superfamily
391 502 CDD cd03143 A4_beta-galactosidase_middle_domain
386 602 Gene3D G3DSA:3.40.50.880 -
386 602 InterPro IPR029062 Class I glutamine amidotransferase-like
1 669 PIRSF PIRSF001084 B-galactosidase
1 669 InterPro IPR003476 Glycoside hydrolase, family 42

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A6A8EF82
AlphaFold — — full sequence — Viewing
ColabFold KP13_01241
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.479
3 0.213

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 21.85 0.875
2 6.66 0.338
3 4.26 0.175
4 1.94 0.04
5 1.91 0.039