Protein profile

KP13_01238

hypothetical protein

Genome: KpKP13

Gene: AHE46698.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GMF0
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Amino acids 185
Annotations 0
Features 12
PDB binders 0
Druggability 0.961

Overview

Basic information about this protein and its source genome.

Accession
KP13_01238
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46698.1
Status
annotated
Amino acids
185
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
47.853
DEG E-value
4.31e-50
Localization
Unknown
ColabFold pLDDT
92.53

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.961
Structure A0A0H3GMF0
Pocket Pocket 2
P2Rank 0.808
Structure A0A0H3GMF0
Pocket Pocket 1
ColabFold model
FPocket 0.995 · Pocket 1
P2Rank 0.813 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 136 / 4744 genomes with a hit
Normalized 0.029

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
1 20 SignalP_EUK SignalP-noTM SignalP-noTM
18 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
23 185 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 20 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
41 182 Gene3D G3DSA:3.40.30.10 Glutaredoxin
1 183 NCBIfam TIGR01626 YtfJ family protein
1 183 InterPro IPR006513 YtfJ-like family
6 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
25 181 Pfam PF09695 Bacterial protein of unknown function (YtfJ_HI0045)
25 181 InterPro IPR006513 YtfJ-like family

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GMF0
AlphaFold — — full sequence — Viewing
ColabFold KP13_01238
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.961

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.12 0.64