Protein profile

KP13_01231

Regulator of cell morphogenesis and NO signaling

Genome: KpKP13

Gene: AHE46704.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GHD7
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Amino acids 220
Annotations 5
Features 13
PDB binders 1
Druggability 0.57

Overview

Basic information about this protein and its source genome.

Accession
KP13_01231
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46704.1
Status
annotated
Amino acids
220
Structure source
AlphaFold + ColabFold
GO
GO:0030091 The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046872 Binding to a metal ion. GO:0051409 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions. GO:0006979 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
87.273
DEG E-value
1.31e-149
Localization
Cytoplasmic
ColabFold pLDDT
97.19

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.57
Structure A0A0H3GHD7
Pocket Pocket 1
P2Rank 0.33
Structure A0A0H3GHD7
Pocket Pocket 1
ColabFold model
FPocket 0.702 · Pocket 1
P2Rank 0.33 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 107 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0030091 The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0046872 Binding to a metal ion.
  • GO:0051409 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.
  • GO:0006979 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
78 214 CDD cd12108 Hr-like
1 220 Hamap MF_01606 Iron-sulfur cluster repair protein YtfE [ytfE].
1 220 InterPro IPR023742 Iron-sulfur cluster repair protein YftE
74 219 FunFam G3DSA:1.20.120.520:FF:000001 Iron-sulfur cluster repair protein YtfE
77 216 Pfam PF01814 Hemerythrin HHE cation binding domain
77 216 InterPro IPR012312 Hemerythrin-like
8 216 NCBIfam TIGR03652 iron-sulfur cluster repair di-iron protein
8 216 InterPro IPR019903 Repair of iron centres family
1 217 PANTHER PTHR36438 IRON-SULFUR CLUSTER REPAIR PROTEIN YTFE
1 217 InterPro IPR019903 Repair of iron centres family
5 58 Pfam PF04405 Domain of Unknown function (DUF542)
5 58 InterPro IPR019903 Repair of iron centres family
75 218 Gene3D G3DSA:1.20.120.520 nmb1532 protein domain like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GHD7
AlphaFold — — full sequence — Viewing
ColabFold KP13_01231
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.57
8 0.009
10 0.0
13 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.47 0.33
2 6.46 0.274

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
O
5FNY
P69506 18.0 Da LogP -0.82 TPSA 31.5 ✓ Ro5 ✓ Clean O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.