Protein profile

KP13_01227

Opacity-associated protein

Genome: KpKP13

Gene: AHE46707.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GME3
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Amino acids 224
Annotations 1
Features 11
PDB binders 0
Druggability 0.677

Overview

Basic information about this protein and its source genome.

Accession
KP13_01227
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46707.1
Status
annotated
Amino acids
224
Structure source
AlphaFold + ColabFold
GO
GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Extracellular
ColabFold pLDDT
66.31

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.677
Structure A0A0H3GME3
Pocket Pocket 12
P2Rank
Structure A0A0H3GME3
Pocket No pockets
ColabFold model
FPocket 0.707 · Pocket 6
P2Rank 0.007 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 62 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
23 50 Pfam PF08525 Opacity-associated protein A N-terminal motif
23 50 InterPro IPR013731 Opacity-associated protein A, N-terminal
139 223 Pfam PF04225 Opacity-associated protein A LysM-like domain
139 223 InterPro IPR007340 Opacity-associated protein A
109 140 MobiDBLite mobidb-lite consensus disorder prediction
55 140 MobiDBLite mobidb-lite consensus disorder prediction
30 48 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
128 222 Gene3D G3DSA:3.10.450.350 -
1 29 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
49 224 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
55 95 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GME3
AlphaFold — — full sequence — Viewing
ColabFold KP13_01227
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.677