Overview
Basic information about this protein and its source genome.
- Accession
- KP13_01224
- Gene
- priB AHE46710.1
- Status
- annotated
- Amino acids
- 104
- Structure source
- Experimental + ColabFold
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Human identity (%)
- 0.0
- Gut microbiome off-target
- hit
- Essential (DEG)
- Y
- DEG identity (%)
- 93.269
- DEG E-value
- 1.0400000000000001e-70
- Localization
- Unknown
- ColabFold pLDDT
- 94.62
Selected Druggability evidence
PDB experimental structureSelected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
Gene Ontology (GO)
3- GO:0030894 A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.
- GO:0006260 The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
- GO:0003697 Binding to single-stranded DNA.
Sequence Features
Domain/signature hits from InterPro and related databases.
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 2 | 100 | Hamap | MF_00720 | Primosomal replication protein N [priB]. |
| 2 | 100 | InterPro | IPR023646 | Primosomal replication protein PriB |
| 3 | 99 | NCBIfam | TIGR04418 | primosomal replication protein N |
| 3 | 99 | InterPro | IPR023646 | Primosomal replication protein PriB |
| 1 | 103 | SUPERFAMILY | SSF50249 | Nucleic acid-binding proteins |
| 1 | 103 | InterPro | IPR012340 | Nucleic acid-binding, OB-fold |
| 1 | 104 | FunFam | G3DSA:2.40.50.140:FF:000077 | Primosomal replication protein N |
| 3 | 88 | Pfam | PF00436 | Single-strand binding protein family |
| 3 | 88 | InterPro | IPR000424 | Primosome PriB/single-strand DNA-binding |
| 1 | 101 | PIRSF | PIRSF003135 | Primosomal_n |
| 1 | 101 | InterPro | IPR023646 | Primosomal replication protein PriB |
| 1 | 101 | ProSiteProfiles | PS50935 | Single-strand binding (SSB) domain profile. |
| 1 | 101 | InterPro | IPR000424 | Primosome PriB/single-strand DNA-binding |
| 1 | 104 | Gene3D | G3DSA:2.40.50.140 | - |
| 1 | 104 | InterPro | IPR012340 | Nucleic acid-binding, OB-fold |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Structural evidence
1 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 1 | 0.366 |
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 1 | 0.282 |
Ligand evidence
Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.
Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.
No PDB structure with a co-crystallized ligand found for this exact protein.
Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.
No PDB ligands found through similar proteins.
Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL bioactivity data found for this exact protein.
Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL hits found through similar proteins.
Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).
| Ligand | Tanimoto | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|
| ZINC5131766 | 0.538 | 224.3 Da LogP -1.26 TPSA 92.4 | ✓ Ro5 | ✓ Clean |
N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)O
|
| ZINC1730666 | 0.524 | 208.2 Da LogP -1.46 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CSC[C@H](N)C(=O)O)C(=O)O
|
| ZINC1730667 | 0.524 | 208.2 Da LogP -1.46 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@H](CSC[C@H](N)C(=O)O)C(=O)O
|
| ZINC1730669 | 0.524 | 208.2 Da LogP -1.46 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@H](CSC[C@@H](N)C(=O)O)C(=O)O
|
| ZINC3055005 | 0.524 | 204.2 Da LogP -0.63 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCC[C@H](N)C(=O)O)C(=O)O
|
| ZINC3055007 | 0.524 | 204.2 Da LogP -0.63 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCC[C@@H](N)C(=O)O)C(=O)O
|
| ZINC3055010 | 0.524 | 204.2 Da LogP -0.63 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@H](CCCC[C@@H](N)C(=O)O)C(=O)O
|
| ZINC1555366 | 0.500 | 232.3 Da LogP 0.15 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCCC[C@H](N)C(=O)O)C(=O)O
|
| ZINC1555367 | 0.500 | 232.3 Da LogP 0.15 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCCC[C@@H](N)C(=O)O)C(=O)O
|
| ZINC1555369 | 0.500 | 232.3 Da LogP 0.15 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@H](CCCCCC[C@@H](N)C(=O)O)C(=O)O
|
| ZINC1720127 | 0.500 | 218.3 Da LogP -0.24 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCC[C@H](N)C(=O)O)C(=O)O
|
| ZINC1720128 | 0.500 | 218.3 Da LogP -0.24 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCC[C@@H](N)C(=O)O)C(=O)O
|
| ZINC1720130 | 0.500 | 218.3 Da LogP -0.24 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@H](CCCCC[C@@H](N)C(=O)O)C(=O)O
|
| ZINC3623257 | 0.500 | 202.2 Da LogP -0.85 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](C/C=C/C[C@@H](N)C(=O)O)C(=O)O
|
| ZINC40439568 | 0.500 | 208.2 Da LogP -2.19 TPSA 112.7 | ✓ Ro5 | ✓ Clean |
N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)O
|
| ZINC4580672 | 0.500 | 202.2 Da LogP -0.85 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](C/C=C/C[C@H](N)C(=O)O)C(=O)O
|
| ZINC4580676 | 0.500 | 202.2 Da LogP -0.85 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@H](C/C=C/C[C@@H](N)C(=O)O)C(=O)O
|
PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.