Protein profile

KP13_01223

30S ribosomal protein S6

Genome: KpKP13

Gene: AHE46711.1 rpsF Structure source: AlphaFold + ColabFold UniProt A0A0H3GQP2
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Amino acids 131
Annotations 6
Features 19
PDB binders 0
Druggability 0.302

Overview

Basic information about this protein and its source genome.

Accession
KP13_01223
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46711.1 rpsF
Status
annotated
Amino acids
131
Structure source
AlphaFold + ColabFold
GO
GO:0019843 Binding to a ribosomal RNA. GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome. GO:0022627 The small subunit of a ribosome located in the cytosol. GO:0070181 Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
93.893
DEG E-value
1.5699999999999999e-90
Localization
Cytoplasmic
ColabFold pLDDT
86.92

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.302
Structure A0A0H3GQP2
Pocket Pocket 2
P2Rank
Structure A0A0H3GQP2
Pocket No pockets
ColabFold model
FPocket 0.524 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 273 / 4744 genomes with a hit
Normalized 0.058

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0019843 Binding to a ribosomal RNA.
  • GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
  • GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
  • GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome.
  • GO:0022627 The small subunit of a ribosome located in the cytosol.
  • GO:0070181 Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
1 115 FunFam G3DSA:3.30.70.60:FF:000003 30S ribosomal protein S6
1 103 SUPERFAMILY SSF54995 Ribosomal protein S6
1 103 InterPro IPR035980 Ribosomal protein S6 superfamily
1 94 Hamap MF_00360 30S ribosomal protein S6 [rpsF].
1 94 InterPro IPR020814 Ribosomal protein S6, plastid/chloroplast
1 101 PANTHER PTHR21011 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6
1 101 InterPro IPR000529 Ribosomal protein S6
43 52 ProSitePatterns PS01048 Ribosomal protein S6 signature.
43 52 InterPro IPR020815 Ribosomal protein S6, conserved site
3 91 CDD cd00473 bS6
3 91 InterPro IPR020814 Ribosomal protein S6, plastid/chloroplast
99 131 MobiDBLite mobidb-lite consensus disorder prediction
100 120 MobiDBLite mobidb-lite consensus disorder prediction
1 94 NCBIfam TIGR00166 30S ribosomal protein S6
1 94 InterPro IPR000529 Ribosomal protein S6
1 116 Gene3D G3DSA:3.30.70.60 -
1 116 InterPro IPR014717 Translation elongation factor EF1B/ribosomal protein S6
3 91 Pfam PF01250 Ribosomal protein S6
3 91 InterPro IPR000529 Ribosomal protein S6

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQP2
AlphaFold — — full sequence — Viewing
ColabFold KP13_01223
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.302