Protein profile

KP13_01219

L-ribulose-5-phosphate 4-epimerase ulaF

Genome: KpKP13

Gene: AHE46715.1 ulaF Structure source: AlphaFold + ColabFold UniProt A0A0H3GLH9
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Amino acids 228
Annotations 7
Features 13
PDB binders 2
Druggability 0.833

Overview

Basic information about this protein and its source genome.

Accession
KP13_01219
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46715.1 ulaF
Status
annotated
Amino acids
228
Structure source
AlphaFold + ColabFold
EC
5.1.3.4
GO
GO:0008742 Catalysis of the reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016832 Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. GO:0008270 Binding to a zinc ion (Zn). GO:0019854 The chemical reactions and pathways resulting in the breakdown of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions. GO:0019323 The chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
96.08

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.833
Structure A0A0H3GLH9
Pocket Pocket 2
P2Rank 0.367
Structure A0A0H3GLH9
Pocket Pocket 1
ColabFold model
FPocket 0.653 · Pocket 1
P2Rank 0.432 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 1214 / 4744 genomes with a hit
Normalized 0.256

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0008742 Catalysis of the reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0016832 Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone.
  • GO:0008270 Binding to a zinc ion (Zn).
  • GO:0019854 The chemical reactions and pathways resulting in the breakdown of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.
  • GO:0019323 The chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 227 Gene3D G3DSA:3.40.225.10 -
1 227 InterPro IPR036409 Class II aldolase/adducin N-terminal domain superfamily
6 194 SMART SM01007 Aldolase_II_2
6 194 InterPro IPR001303 Class II aldolase/adducin N-terminal
1 228 Hamap MF_01952 L-ribulose-5-phosphate 4-epimerase UlaF [ulaF].
1 228 InterPro IPR023499 L-ribulose-5-phosphate 4-epimerase UlaF
2 219 SUPERFAMILY SSF53639 AraD/HMP-PK domain-like
2 219 InterPro IPR036409 Class II aldolase/adducin N-terminal domain superfamily
2 226 PANTHER PTHR22789 FUCULOSE PHOSPHATE ALDOLASE
1 227 FunFam G3DSA:3.40.225.10:FF:000001 L-ribulose-5-phosphate 4-epimerase UlaF
2 219 CDD cd00398 Aldolase_II
7 193 Pfam PF00596 Class II Aldolase and Adducin N-terminal domain
7 193 InterPro IPR001303 Class II aldolase/adducin N-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLH9
AlphaFold — — full sequence — Viewing
ColabFold KP13_01219
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.833

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.11 0.166
2 2.18 0.052
3 2.06 0.046

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

2 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
13P
1E47
P0AB87 170.1 Da LogP -1.34 TPSA 104.1 ✓ Ro5 ✓ Clean C(C(=O)COP(=O)(O)O)O
PGH
4FUA
P0AB87 171.0 Da LogP -1.40 TPSA 116.1 ✓ Ro5 ✓ Clean C(C(=O)NO)OP(=O)(O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.