Protein profile

KP13_01216

Ascorbate-specific phosphotransferase enzyme IIA component

Genome: KpKP13

Gene: ulaC AHE46718.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GI37
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Amino acids 155
Annotations 3
Features 14
PDB binders 0
Druggability 0.297

Overview

Basic information about this protein and its source genome.

Accession
KP13_01216
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ulaC AHE46718.1
Status
annotated
Amino acids
155
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0009401 The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
92.95

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.297
Structure A0A0H3GI37
Pocket Pocket 1
P2Rank 0.255
Structure A0A0H3GI37
Pocket Pocket 1
ColabFold model
FPocket 0.315 · Pocket 8
P2Rank 0.284 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 65 / 4744 genomes with a hit
Normalized 0.014

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
  • GO:0009401 The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
53 69 ProSitePatterns PS00372 PTS EIIA domains phosphorylation site signature 2.
53 69 InterPro IPR002178 PTS EIIA type-2 domain
6 150 ProSiteProfiles PS51094 PTS_EIIA type-2 domain profile.
6 150 InterPro IPR002178 PTS EIIA type-2 domain
1 153 FunFam G3DSA:3.40.930.10:FF:000005 Ascorbate-specific phosphotransferase enzyme IIA component
5 151 PANTHER PTHR36203 ASCORBATE-SPECIFIC PTS SYSTEM EIIA COMPONENT
7 149 SUPERFAMILY SSF55804 Phoshotransferase/anion transport protein
7 149 InterPro IPR016152 Phosphotransferase/anion transporter
10 147 CDD cd00211 PTS_IIA_fru
10 147 InterPro IPR002178 PTS EIIA type-2 domain
7 149 Pfam PF00359 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
7 149 InterPro IPR002178 PTS EIIA type-2 domain
1 153 Gene3D G3DSA:3.40.930.10 -
1 153 InterPro IPR016152 Phosphotransferase/anion transporter

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GI37
AlphaFold — — full sequence — Viewing
ColabFold KP13_01216
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.297
2 0.209

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.75 0.032