Protein profile

KP13_01212

putative L-ascorbate-6-phosphate lactonase ulaG

Genome: KpKP13

Gene: AHE46722.1 ulaG Structure source: AlphaFold + ColabFold UniProt A0A0H3GHA2
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Amino acids 354
Annotations 3
Features 8
PDB binders 0
Druggability 0.633

Overview

Basic information about this protein and its source genome.

Accession
KP13_01212
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46722.1 ulaG
Status
annotated
Amino acids
354
Structure source
AlphaFold + ColabFold
GO
GO:0035460 Catalysis of the reaction: L-ascorbate 6-phosphate + H2O = 3-keto-L-gulonate 6-phosphate. GO:0030145 Binding to a manganese ion (Mn). GO:0019854 The chemical reactions and pathways resulting in the breakdown of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
97.94

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.633
Structure A0A0H3GHA2
Pocket Pocket 11
P2Rank 0.805
Structure A0A0H3GHA2
Pocket Pocket 1
ColabFold model
FPocket 0.631 · Pocket 13
P2Rank 0.834 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 221 / 4744 genomes with a hit
Normalized 0.047

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0035460 Catalysis of the reaction: L-ascorbate 6-phosphate + H2O = 3-keto-L-gulonate 6-phosphate.
  • GO:0030145 Binding to a manganese ion (Mn).
  • GO:0019854 The chemical reactions and pathways resulting in the breakdown of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
32 323 PANTHER PTHR43546 UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED
3 354 FunFam G3DSA:3.60.15.10:FF:000004 Probable L-ascorbate-6-phosphate lactonase UlaG
42 281 Pfam PF13483 Beta-lactamase superfamily domain
37 249 CDD cd16284 UlaG-like_MBL-fold
36 302 SUPERFAMILY SSF56281 Metallo-hydrolase/oxidoreductase
36 302 InterPro IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
3 354 Gene3D G3DSA:3.60.15.10 -
3 354 InterPro IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GHA2
AlphaFold — — full sequence — Viewing
ColabFold KP13_01212
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
13 0.562
5 0.007
1 0.0
21 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 21.18 0.805
2 2.07 0.038
3 1.65 0.022
4 1.38 0.014
5 1.33 0.013