Protein profile

KP13_32182

Protein hfq

Genome: KpKP13

Gene: hfq AHE46738.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQJ6
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Amino acids 102
Annotations 5
Features 18
PDB binders 5
Druggability 0.221

Overview

Basic information about this protein and its source genome.

Accession
KP13_32182
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
hfq AHE46738.1
Status
annotated
Amino acids
102
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003723 Binding to an RNA molecule or a portion thereof. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0043487 Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs. GO:0045974 Any process, mediated by small non-coding RNAs, that modulates the frequency, rate or extent that mRNAs are effectively translated into protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
92.233
DEG E-value
3.3700000000000004e-64
Localization
Cytoplasmic
ColabFold pLDDT
79.89

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.221
Structure A0A0H3GQJ6
Pocket Pocket 5
P2Rank
Structure A0A0H3GQJ6
Pocket No pockets
ColabFold model
FPocket 0.504 · Pocket 4
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 54 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003723 Binding to an RNA molecule or a portion thereof.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0043487 Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs.
  • GO:0045974 Any process, mediated by small non-coding RNAs, that modulates the frequency, rate or extent that mRNAs are effectively translated into protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
1 75 FunFam G3DSA:2.30.30.100:FF:000001 RNA-binding protein Hfq
9 68 ProSiteProfiles PS52002 Sm domain profile.
9 68 InterPro IPR047575 Sm domain
5 64 NCBIfam TIGR02383 RNA chaperone Hfq
5 64 InterPro IPR005001 RNA-binding protein Hfq
65 102 MobiDBLite mobidb-lite consensus disorder prediction
7 69 SUPERFAMILY SSF50182 Sm-like ribonucleoproteins
7 69 InterPro IPR010920 LSM domain superfamily
6 64 CDD cd01716 Hfq
6 64 InterPro IPR005001 RNA-binding protein Hfq
1 72 Gene3D G3DSA:2.30.30.100 -
3 64 Hamap MF_00436 RNA-binding protein Hfq [hfq].
3 64 InterPro IPR005001 RNA-binding protein Hfq
63 102 MobiDBLite mobidb-lite consensus disorder prediction
1 75 PANTHER PTHR34772 RNA-BINDING PROTEIN HFQ
1 75 InterPro IPR005001 RNA-binding protein Hfq
7 69 Pfam PF17209 Hfq protein
7 69 InterPro IPR005001 RNA-binding protein Hfq

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQJ6
AlphaFold — — full sequence — Viewing
ColabFold KP13_32182
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.221

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

55 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
ADE
3QUI
Q9HUM0 135.1 Da LogP -0.06 TPSA 80.5 ✓ Ro5 ✓ Clean c1[nH]c2c(n1)c(ncn2)N
ANP
3QUI
Q9HUM0 506.2 Da LogP -2.06 TPSA 281.9 3 viol. ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)…
GUN
6QLB
P0A6X3 151.1 Da LogP -0.77 TPSA 100.5 ✓ Ro5 ✓ Clean c1[nH]c2c(n1)C(=O)NC(=N2)N
NHE
3GIB
P0A6X3 207.3 Da LogP 0.80 TPSA 66.4 ✓ Ro5 ✓ Clean C1CCC(CC1)NCCS(=O)(=O)O
U
2YLC
P0A1R0 324.2 Da LogP -2.73 TPSA 171.3 ✓ Ro5 ✓ Clean C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)C…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.