Protein profile

KP13_00508

Entericidin B

Genome: KpKP13

Gene: ecnB AHE46757.1 Structure source: AlphaFold + ColabFold UniProt A0A080SRG4
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Amino acids 63
Annotations 2
Features 8
PDB binders 0
Druggability 0.822

Overview

Basic information about this protein and its source genome.

Accession
KP13_00508
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ecnB AHE46757.1
Status
annotated
Amino acids
63
Structure source
AlphaFold + ColabFold
GO
GO:0009636 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
83.51

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.822
Structure A0A080SRG4
Pocket Pocket 1
P2Rank
Structure A0A080SRG4
Pocket No pockets
ColabFold model
FPocket 0.749 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 57 / 4744 genomes with a hit
Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0009636 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
20 30 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
39 58 Pfam PF08085 Entericidin EcnA/B family
39 58 InterPro IPR012556 Entericidin A/B
1 35 Phobius SIGNAL_PEPTIDE Signal peptide region
36 63 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 19 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
31 35 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A080SRG4
AlphaFold — — full sequence — Viewing
ColabFold KP13_00508
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.822