Protein profile

KP13_00506

putative kamA family protein

Genome: KpKP13

Gene: AHE46759.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQG9
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Amino acids 342
Annotations 5
Features 21
PDB binders 0
Druggability 0.955

Overview

Basic information about this protein and its source genome.

Accession
KP13_00506
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46759.1
Status
annotated
Amino acids
342
Structure source
AlphaFold + ColabFold
GO
GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016853 Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
58.385
DEG E-value
2.85e-145
Localization
Cytoplasmic
ColabFold pLDDT
95.08

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.955
Structure A0A0H3GQG9
Pocket Pocket 1
P2Rank 0.979
Structure A0A0H3GQG9
Pocket Pocket 1
ColabFold model
FPocket 0.972 · Pocket 2
P2Rank 0.985 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 142 / 4744 genomes with a hit
Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
  • GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.
  • GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
  • GO:0016853 Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
118 262 Pfam PF04055 Radical SAM superfamily
118 262 InterPro IPR007197 Radical SAM
9 336 SFLD SFLDF00314 L-lysine 2,3-aminomutase (yjeK like)
9 336 InterPro IPR022462 Lysine-2,3-aminomutase-like
51 334 Gene3D G3DSA:3.20.20.70 Aldolase class I
51 334 InterPro IPR013785 Aldolase-type TIM barrel
3 328 NCBIfam TIGR00238 KamA family radical SAM protein
3 328 InterPro IPR003739 Lysine-2,3-aminomutase/glutamate 2,3-aminomutase
9 336 SFLD SFLDG01070 PLP-dependent
9 336 InterPro IPR003739 Lysine-2,3-aminomutase/glutamate 2,3-aminomutase
106 329 ProSiteProfiles PS51918 Radical SAM core domain profile.
106 329 InterPro IPR007197 Radical SAM
1 342 PIRSF PIRSF004911 L-lysine_2_3-aminomutase
1 342 InterPro IPR003739 Lysine-2,3-aminomutase/glutamate 2,3-aminomutase
112 177 Pfam PF13353 4Fe-4S single cluster domain
102 324 SUPERFAMILY SSF102114 Radical SAM enzymes
9 335 PANTHER PTHR30538 LYSINE 2,3-AMINOMUTASE-RELATED
9 335 InterPro IPR003739 Lysine-2,3-aminomutase/glutamate 2,3-aminomutase
15 335 NCBIfam TIGR03821 EF-P beta-lysylation protein EpmB
15 335 InterPro IPR022462 Lysine-2,3-aminomutase-like
114 311 CDD cd01335 Radical_SAM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQG9
AlphaFold — — full sequence — Viewing
ColabFold KP13_00506
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.955
4 0.245

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 40.36 0.964
2 1.64 0.027