Protein profile

KP13_00505

Two-component response regulator

Genome: KpKP13

Gene: AHE46760.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GHZ2
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Amino acids 231
Annotations 3
Features 16
PDB binders 0
Druggability 0.441

Overview

Basic information about this protein and its source genome.

Accession
KP13_00505
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46760.1
Status
annotated
Amino acids
231
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
72.21

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.441
Structure A0A0H3GHZ2
Pocket Pocket 1
P2Rank
Structure A0A0H3GHZ2
Pocket No pockets
ColabFold model
FPocket 0.57 · Pocket 10
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 3 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
49 126 SMART SM00862 Trans_reg_C_3
49 126 InterPro IPR001867 OmpR/PhoB-type DNA-binding domain
207 229 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
48 124 CDD cd00383 trans_reg_C
48 124 InterPro IPR001867 OmpR/PhoB-type DNA-binding domain
1 206 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
230 231 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
50 124 Pfam PF00486 Transcriptional regulatory protein, C terminal
50 124 InterPro IPR001867 OmpR/PhoB-type DNA-binding domain
48 124 SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators
48 124 InterPro IPR016032 Signal transduction response regulator, C-terminal effector
207 229 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
28 129 Gene3D G3DSA:1.10.10.10 -
28 129 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
25 128 ProSiteProfiles PS51755 OmpR/PhoB-type DNA-binding domain profile.
25 128 InterPro IPR001867 OmpR/PhoB-type DNA-binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GHZ2
AlphaFold — — full sequence — Viewing
ColabFold KP13_00505
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.441