Protein profile

KP13_00501

Outer membrane usher protein lpfC

Genome: KpKP13

Gene: lpfC AHE46764.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GH65
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Amino acids 847
Annotations 5
Features 30
PDB binders 0
Druggability 0.873

Overview

Basic information about this protein and its source genome.

Accession
KP13_00501
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
lpfC AHE46764.1
Status
annotated
Amino acids
847
Structure source
AlphaFold + ColabFold
GO
GO:0005515 Binding to a protein. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone. GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
OuterMembrane
ColabFold pLDDT
85.36

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.873
Structure A0A0H3GH65
Pocket Pocket 11
P2Rank 0.2
Structure A0A0H3GH65
Pocket Pocket 1
ColabFold model
FPocket 0.67 · Pocket 25
P2Rank 0.137 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 9 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005515 Binding to a protein.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone.
  • GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles.
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records
Show feature table
Start End DB Term Name
54 176 Gene3D G3DSA:3.10.20.410 -
54 176 InterPro IPR037224 PapC, N-terminal domain superfamily
36 188 Pfam PF13954 PapC N-terminal domain
36 188 InterPro IPR025885 PapC, N-terminal domain
270 359 FunFam G3DSA:2.60.40.3110:FF:000001 Putative fimbrial outer membrane usher
765 831 Pfam PF13953 PapC C-terminal domain
765 831 InterPro IPR025949 PapC-like, C-terminal domain
62 179 SUPERFAMILY SSF141729 FimD N-terminal domain-like
62 179 InterPro IPR037224 PapC, N-terminal domain superfamily
11 23 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 32 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
54 176 FunFam G3DSA:3.10.20.410:FF:000001 Fimbrial outer membrane usher protein
761 847 Gene3D G3DSA:2.60.40.2070 -
761 847 InterPro IPR043142 PapC-like, C-terminal domain superfamily
10 846 PANTHER PTHR30451 OUTER MEMBRANE USHER PROTEIN
10 846 InterPro IPR000015 Outer membrane usher protein
33 847 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 10 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
24 32 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
670 760 Gene3D G3DSA:2.60.40.2610 Outer membrane usher protein FimD, plug domain
670 760 InterPro IPR042186 Outer membrane usher protein FimD, plug domain
1 32 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
270 358 Gene3D G3DSA:2.60.40.3110 -
7 26 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
670 760 FunFam G3DSA:2.60.40.2610:FF:000001 Outer membrane fimbrial usher protein
201 754 Pfam PF00577 Outer membrane usher protein
201 754 InterPro IPR000015 Outer membrane usher protein
312 322 ProSitePatterns PS01151 Fimbrial biogenesis outer membrane usher protein signature.
312 322 InterPro IPR018030 Fimbrial membrane usher, conserved site
1 32 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GH65
AlphaFold — — full sequence — Viewing
ColabFold KP13_00501
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.873
7 0.475
52 0.47
10 0.263

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.61 0.076
2 2.01 0.044
3 1.76 0.032
4 1.57 0.024
5 1.29 0.013