Protein profile

KP13_00490

suppressor of F exclusion of phage T7

Genome: KpKP13

Gene: fxsA AHE46775.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQF5
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Amino acids 163
Annotations 1
Features 16
PDB binders 0
Druggability 0.945

Overview

Basic information about this protein and its source genome.

Accession
KP13_00490
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
fxsA AHE46775.1
Status
annotated
Amino acids
163
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
76.84

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.945
Structure A0A0H3GQF5
Pocket Pocket 5
P2Rank 0.002
Structure A0A0H3GQF5
Pocket Pocket 1
ColabFold model
FPocket 0.774 · Pocket 2
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 111 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
7 154 PANTHER PTHR35335 UPF0716 PROTEIN FXSA
7 154 InterPro IPR007313 FxsA cytoplasmic membrane protein
13 116 Pfam PF04186 FxsA cytoplasmic membrane protein
13 116 InterPro IPR007313 FxsA cytoplasmic membrane protein
53 82 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
107 163 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
142 163 MobiDBLite mobidb-lite consensus disorder prediction
33 52 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
31 53 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
135 163 MobiDBLite mobidb-lite consensus disorder prediction
4 26 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
6 26 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
83 106 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
84 106 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
27 32 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQF5
AlphaFold — — full sequence — Viewing
ColabFold KP13_00490
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.945
2 0.455
3 0.253