Protein profile

KP13_00487

Anaerobic C4-dicarboxylate transporter dcuA

Genome: KpKP13

Gene: AHE46778.1 dcuA Structure source: AlphaFold + ColabFold UniProt A0A0H3GL82
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Amino acids 433
Annotations 4
Features 41
PDB binders 0
Druggability 0.813

Overview

Basic information about this protein and its source genome.

Accession
KP13_00487
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46778.1 dcuA
Status
annotated
Amino acids
433
Structure source
AlphaFold + ColabFold
GO
GO:0015740 The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015556 Enables the transfer of C4-dicarboxylate from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
93.78

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.813
Structure A0A0H3GL82
Pocket Pocket 27
P2Rank 0.939
Structure A0A0H3GL82
Pocket Pocket 1
ColabFold model
FPocket 0.823 · Pocket 8
P2Rank 0.901 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 278 / 4744 genomes with a hit
Normalized 0.059

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0015740 The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015556 Enables the transfer of C4-dicarboxylate from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

41 records
Show feature table
Start End DB Term Name
327 345 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
429 433 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 433 PANTHER PTHR36106 ANAEROBIC C4-DICARBOXYLATE TRANSPORTER DCUB
1 433 InterPro IPR004668 Anaerobic c4-dicarboxylate membrane transporter
346 356 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
359 381 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
131 157 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
40 45 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
357 384 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
404 428 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
46 67 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
163 190 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
250 260 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
227 249 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 433 PIRSF PIRSF004539 Anaerob_C4-dicrbxlt_transp
284 306 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
260 277 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
191 226 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
87 110 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
278 288 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
308 326 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
5 433 NCBIfam TIGR00770 anaerobic C4-dicarboxylate transporter
5 433 InterPro IPR004668 Anaerobic c4-dicarboxylate membrane transporter
6 39 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
226 245 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 365 Pfam PF03605 Anaerobic c4-dicarboxylate membrane transporter
5 365 InterPro IPR004668 Anaerobic c4-dicarboxylate membrane transporter
111 130 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
46 68 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
68 86 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
329 346 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
158 162 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
289 307 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
168 190 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
261 277 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
409 431 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
131 153 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
385 403 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
20 39 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
88 110 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GL82
AlphaFold — — full sequence — Viewing
ColabFold KP13_00487
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
27 0.813
1 0.487
24 0.445
6 0.4

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 18.46 0.823
2 17.9 0.81
3 3.17 0.108
4 3.12 0.105
5 1.81 0.034