Protein profile

KP13_00474

Biofilm PGA synthesis protein pgaA

Genome: KpKP13

Gene: AHE46792.1 pgaA Structure source: AlphaFold + ColabFold UniProt A0A0H3GM58
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Amino acids 822
Annotations 2
Features 9
PDB binders 0
Druggability 0.239

Overview

Basic information about this protein and its source genome.

Accession
KP13_00474
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46792.1 pgaA
Status
annotated
Amino acids
822
Structure source
AlphaFold + ColabFold
GO
GO:1901515 Enables the transfer of poly-beta-1,6-N-acetyl-D-glucosamine from one side of a membrane to the other. GO:0005515 Binding to a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
91.25

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.239
Structure A0A0H3GM58
Pocket Pocket 53
P2Rank 0.583
Structure A0A0H3GM58
Pocket Pocket 1
ColabFold model
FPocket 0.593 · Pocket 67
P2Rank 0.468 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 30 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:1901515 Enables the transfer of poly-beta-1,6-N-acetyl-D-glucosamine from one side of a membrane to the other.
  • GO:0005515 Binding to a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
36 41 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 41 Phobius SIGNAL_PEPTIDE Signal peptide region
40 587 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
40 587 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
25 822 NCBIfam TIGR03939 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA
25 822 InterPro IPR023870 Poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA
1 24 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
42 822 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
25 35 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GM58
AlphaFold — — full sequence — Viewing
ColabFold KP13_00474
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
53 0.239

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.7 0.341
2 5.69 0.275
3 5.32 0.251
4 4.56 0.196
5 3.28 0.115